Volume Cream by Adipeau

Restore lost volume from within

The Volume Cream is built around two actives validated in human adipocyte studies at the Karolinska Institute.

Beneath the surface of your skin sits a layer of fat cells that most skincare has never addressed. This dermal fat layer supports facial structure, signals fibroblasts to produce collagen and elastin, and gives the skin its natural lift and softness. With age, sun exposure and daily life, this tissue loses function. The cells that remain become enlarged and sluggish. The ones that should replace them do not arrive. The result is a progressive loss of the inner scaffolding that holds your face in shape. 

The Adipeau Volume Cream was developed to address this root cause. It works within the dermal fat layer using two clinically studied active ingredients to support fat cell regeneration: the natural renewal of healthy, small, functional adipocytes that form the structural foundation of the skin. 

Long Chain Fatty Acids (LCFAs), derived from organic safflower seed oil (Carthamus Tinctorius), are natural PPARγ agonists. They signal immature fat cell precursors to mature into healthy, functional adipocytes, supporting the regeneration of lost dermal volume. LCFAs enter the skin via the transfollicular route, reaching the depth where dermal fat cells are found. 

Polymethoxyflavonoids (PMFs), derived from wild harvested black ginger (Kaempferia Parviflora), work in a complementary direction. They stimulate the proliferation of immature fat cells and reduce the size of mature, overgrown ones, creating the conditions for a denser population of smaller, healthier cells. In preclinical studies, the combination of both actives doubled fat cell number with no increase in average cell size, consistent with genuine tissue regeneration.

The visible effects: more even volume distribution, reduction in crepe texture, finer pores, and improved glow from skin that is well-nourished from within.

Clinical Evidence

Karolinska Institute in-vitro study Researchers at the Karolinska Institute used a 3D culture model of human adipose tissue to test Adipeau's key actives. In healthy fat tissue models, the combination of Kaempferia Parviflora extract and safflower seed oil fatty acids doubled fat cell number with no increase in average cell size. In models mimicking hypertrophic, dysfunctional fat tissue, Kaempferia Parviflora extract alone doubled cell number and reduced average cell size by over 40%. Gene expression analysis confirmed activation of PPARγ signaling, enhanced extracellular matrix remodeling, and reduced inflammatory and insulin-resistance pathways. Pre-publication manuscript available on request.

3D Facial Volume Clinical Study (ClinicalTrials.gov: NCT04769193) 35 adults aged 25 to 75 applied the formula once or twice daily to the mid and lower face for 6 months, with no fillers or surgery during the study. Facial volume was measured at baseline, 3 months and 6 months using high-resolution 3D imaging at 100-micron resolution.

Volume increased in atrophic areas (median +1.4 cm³ per hemi-face) and decreased in hypertrophic areas (median -0.6 cm³ per hemi-face). Gains were progressive and significantly greater at 6 months than at 3 months (p = 0.03). Older subjects experienced greater volumisation: +0.43 cm³ per decade of age (p = 0.04).

Who is it for?

The Volume Cream is for anyone noticing the signs of dermal fat loss: hollow temples, deepening nasolabial folds, under-eye volume depletion, marionette lines, crepe texture around the mouth and cheeks, or a general loss of natural plumpness. It is also for those who have lost weight and noticed the skin on the face, neck, hands or arms has not recovered, leaving a thinness or sagging that conventional moisturisers have not been able to address.
It works progressively, over weeks and months, rebuilding a tissue layer that took years to deplete.

How to use

Apply once or twice daily using fingertips to spread a thin layer over the target areas. The mid and lower face, under-eye hollows, temple area and mouth lines are the primary zones. It can also be used on the hands, forearms and decolletage where volume depletion is visible.
Allow the cream to sit for approximately 10 minutes before rubbing in any excess. Any remaining product can be worked into the hands.
For best results, begin with the Adipeau Strength Gel alone for 4 to 6 weeks to strengthen the dermal structure before adding the cream. Once the skin has built resilience, alternate the two: gel in the morning, cream at night. For a glow effect, apply the cream as a mask, leave for 10 minutes, then rub in the excess before bed.
Practices that increase blood flow and lymph clearance, such as gua sha, facial acupuncture or red light therapy, amplify results.

What is the Volume Cream actually doing to my skin?
It is nourishing the layer of fat cells that sits just beneath the dermis and acts as the internal scaffolding of your face. When this layer depletes or becomes dysfunctional with age, the skin loses its natural lift, firmness and volume. The cream delivers two actives that signal fat cell precursors to mature and proliferate, restoring a healthier, denser layer of smaller, functional cells. The collagen and elastin benefits follow naturally, because healthy dermal fat cells signal fibroblasts to produce them.
Is this the same as a filler?
No, and the difference is fundamental. A filler adds a foreign substance to create the appearance of volume. The Volume Cream supports your skin in regenerating its own volume, from within, using the body's natural fat cell renewal process. The result builds gradually and does not alter the natural movement or expression of the face.
How long before I notice a difference?
Clinical results showed progressive improvement over 6 months, with significant gains between the 3 and 6 month marks. That said, many people notice a glow effect and improved texture within the first few weeks. Think of the first month as preparation and the following months as where the real transformation happens.
Can I use it around my eyes?
Yes, but with care. The cream can be applied to under-eye hollows and the orbital area, but should not be applied too close to the lash line or inner corner, as it can migrate to the conjunctiva and cause irritation. A small amount applied with the fingertip, patted gently and kept a few millimetres from the eye itself, is the right approach.
Can I use it with my existing skincare?
Yes, with a few important exceptions. The cream is best applied as the last step before sunscreen. Avoid layering it with hyaluronic acid serums, retinoids, caffeine-based products, resveratrol or castor oil, as these can interfere with the adipogenic activity of the formula. If you use a peptide product, apply it first and allow extra time for absorption before applying the cream.
Can I use it alongside other Depuravita products?
Yes. The Volume Cream works beautifully as the topical complement to an inside-out skin ritual. Magic Potion, with its marine collagen peptides, adaptogenic mushrooms and cacao polyphenols, supports skin structure from within and pairs naturally with the outside action of the cream. Hello Wrinkles 3.0, Depuravita's marine collagen drink, works along the same axis and creates a complete regenerative approach when combined with daily topical use.

Ingredients

Active ingredients: Carthamus Tinctorius (Safflower) Seed Oil, Kaempferia Parviflora Rhizome Extract, Cucumis Sativus (Cucumber) Fruit Extract.
Full INCI: Water (Aqua), Carthamus Tinctorius (Safflower) Seed Oil, Dicaprylyl Carbonate, Glycerin, Sunflower Seed Oil, Cetearyl Alcohol, Propanediol, Phenethyl Alcohol, Cucumis Sativus (Cucumber) Fruit Extract, Rice Bran Wax, Tocopheryl Acetate, Kaempferia Parviflora Rhizome Extract, Bis-Diglyceryl Polyacyladipate-2, Xanthan Gum, Glyceryl Oleate Citrate, Polysorbate 20, Carbomer, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Ethylhexylglycerin, Oleic Acid, Propylene Glycol, Sodium Benzoate, Tocopherol, Sodium Hydroxide, Pentylene Glycol.
All active ingredients are EWG rated 1. No added fragrance. The natural scent of Kaempferia Parviflora is balanced by cucumber extract. Format: water-oil emulsion, 60ml.

Adipeau Volume Cream 60ml tube on white background
Before and after Adipeau Volume Cream, mouth lines recede after 4 months of daily use
Adipeau Volume Cream and Strength Gel duo shot, both tubes standing upright
Adipeau Volume Cream and Strength Gel duo shot, synergy shot
Before and after Adipeau Volume Cream, mouth lines recede after 4 months of daily use
Two Adipau antiaging care products on a wooden surface with a blurred background
Before and after Adipeau Volume Cream, nasolabial folds strengthen after 1 month

Real Life Rituals

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A daily ritual of pleasure and precision

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Rehydration – Regeneration – Rejuvenation

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